فعالیت های علمی و مطالعاتی:
پایان نامه دوره Honours با عنوان "Anti-tyrosinase activity of eleven medicinal plants" (1385)
موضوعات مورد بررسی قرار گرفته در این تحقیق شامل موارد زیر می باشند:
a. Evaluation the inhibition of the monophenolase activity (tyrosine) and diphenolase activity (DOPA) of mushroom tyrosinase by plant extracts. (Tyrosinase enzyme assay)
b. Investigate the cytotoxic effect of potent plant extract on melanocyte cells. (Toxicity and effect of plant extracts on melanin synthesis in vitro)
c. Investigate the best plant extract for its ability to inhibit melanin production by melanocyte cells. (Melanocyte cell culture for the investigation of melanin inhibition by plant extracts).
9. پایان نامه دوره کارشناسی ارشد با عنوان
"Plant derived multifunctional actives for skin lightening from C. siliqua and S. inerme" (1386).
موضوعات مورد بررسی قرار گرفته در این تحقیق شامل موارد زیر می باشند:
a. Identification of the traditional South African plants for Melasma treatment.
b. Evaluation of anti-tyrosine activity of plant extracts.
c. Testing plant extracts which has maximum anti-tyrosinase activity for their inhibition of melanin production and cytotoxicity.
d. Isolation and purification of active compounds from the best extracts. Eight pure compounds could be isolated from two extracts which one of them is new (its structure is known but it has been never tested for its anti-tyrosinase or DOPA activity before).
e. Anti-oxidant activity and Radical scavenging capacity of extracts and pure compounds were evaluated.
f. Quantitative Real-time PCR (qRT-PCR) analysis was done to investigate the expression of related pigmentation genes in samples-treated mouse epidermal melanocyte cells.
g. Kinetic parameter of the effect of the plant extract which has maximum anti-tyrosinase activity has been investigated.
3. پایان نامه دوره دکتری با عنوان
A mechanistically evaluation of anticancer activities of Hyaenanche globosa & Maytenus procumbens
The main themes of my research work were to access the cytotoxicity of these plants and their main component toward cancer cells inhibition and their relevance mechanisms of action. Besides their other biological activities were investigated.
موضوعات مورد بررسی قرار گرفته در این تحقیق شامل موارد زیر می باشند:
a. Preparation of plant material, isolation and identification of compounds
b. Cell culture, MTT cytotoxicity assay
c. Cancer cell research
d. Assessment of DNA damage induced by the isolated compounds via apoptosis or necrosis (Annexin V-FITC affinity assay, flow cytometry assay, single cell gel electrophoresis (SCGE)/comet)
e. Assessment of the antioxidant/pro-oxidant activity of plant extract and the isolated compounds extracellular by (DPPH antioxidant assay), and intracellular (in cultured cells); ferric reducing/antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), and measurement of intracellular reactive oxygen species (ROS) assays
f. Assessment of the antibacterial/fungal activities of plant extracts and the isolated compounds (agar-diffusion bioassay)
حضور در کنفرانسهای علمی و پژوهشی
A. Momtaz, S & Lall, N. (13-14 September 2006). Anti-tyrosinase activity of South African plants. International Society of Cosmetic Chemists; Coschem, Johannesburg, South Africa (Oral presentation).
B. Momtaz, S & Lall, N. (November 2006). Anti-tyrosinase activity of eleven South African plants. Post-graduate students Symposium in the University of Pretoria (South Africa) (Oral presentation).
C. Momtaz, S & R.K. Chikwamba. (September 2005). The Importance of Plant Biotechnology in the Development of Biopharmaceuticals. Honours student Symposium in the University of Pretoria (South Africa) (Oral presentation).
D. Momtaz, S & Lall, N. (June 2006). HAIR GROWTH AND NATURAL PRODUCTS. Honours student Symposium in the University of Pretoria (South Africa) (Oral presentation).
E. Momtaz, S, Abdollahi, M & Ostad, SN., (May 2009). CYTOTOXICITY EFFECTS OF HYAENANCHE GLOBOSA AND MAYTENUS PROCUMBENS. 10 th Iranian Toxicology Congress, Tehran (Poster presentation).
F. Saeideh Momtaz, Namrita Lall, Ahmed Hussein, Seyed Nasser Ostad, Mohammad Abdollahi. AN EVALUATION OF ANTI-PROLIFERATIVE
ACTIVITY OF MAYTENUS PROCUMBENS. 47th Eurotox, Paris (Poster presentation).
مقالات:
1) Momtaz, S., Lall, N & Basson, A.E. Inhibitory activities of mushroom tyrosine and DOPA oxidation by plant extracts (2007, South African Journal of Botany).
2) Saeideh Momtaz, Brenda M Mapunya, Peter J Houghton, Christina Edgerly, Ahmed Hussein, Sanushka Naidoo, Namrita Lall. Tyrosinase inhibition by extracts of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening and its constituents (2008, Ethnopharmacology).
3) Lall, N., Kishore, N., Momtaz, S., Hussein, A., Naidoo, S., Nqephe, M & Crampton, B. Extracts from Ceratonia siliqua exhibited Depigmentation (2015, Phytotherapy Research).
4) Momtaz, S., Abdollahi, M. A systematic review of the biological activities of Satureja L. species (2008, Pharmacology online).
5) Saeideh Momtaz, Namrita Lall, Ahmed Hussein, Seyed Naser Ostad and Mohammad Abdollahi. Cytotoxicity and Multi-biochemichal Effects of a Poisonous South African Plant; Hyaenanche globosa (Euphorbiaceae) (2010, Pharmacognosy Magazin).
6) Saeideh Momtaz, Namrita Lall, Ahmed Hussein, Seyed Naser Ostad and Mohammad Abdollahi. Growth inhibition and induction of apoptosis in human cancerous Hela cells by Maytenus procumbens (2012, Food Chemistry and Toxicology).
7) S. Momtaz. Revising utilization of science of plant-based vaccines; reduction in utilization of conventional animal or bacterial systems but biosafety concerns (2011, Asian Journal of Animal and Veterinary Advances).
8) S. Momtaz & M. Abdollahi. A Comprehensive Review of Biochemical and Molecular Evidences from Animal and Human Studies on the Role of Oxidative Stress in Aging: An Epiphenomenon or the Cause (2012, Asian Journal of Animal and Veterinary Advances).
9) Kuldeep Dhama, Kumaragurubaran Karthik, Ruchi Tiwari, Mahmoud Mohamed Alagawany, Mayada Ragab Farag, Amarpal, Yashpal Singh Malik,
Raj Kumar Singh,Vito Laudadio, Vincenzo Tufarelli, Muhammad Sarwar, Saeideh Momtaz, Kamal Niaz and Mohammad Abdollahi. Designer and Functional Foods and Food-Products of Animal Origin for Human Health Benefits: The Advances and Perspectives. (2016, Under publication)
10) Saeideh Momtaz; Niaz, Kamal ; Maqbool, Faheem ; Abdollahi, Mohammad; Rastrelli, Luca; Nabavi, SM. STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma. (2016, BioFactors).
11) Sh hassani, Saeideh Momtaz, F Vakhshiteh, A salek, MR Ganjali, P Norouzi, M Abdollahi. Biosensors and their applications in detection of organophosphorus pesticides in the environment. (2016, Archives of Toxicology).
12) Maryam Baeeri, Saeideh Momtaz, Kamal Niaz, Mona Navaei-Nigjeh, Mahban Rahimifard, Seyedeh Farnaz Ghasemi-Niri, Nima Sanadgol, Mohammad Sharifzadeh, Mohammad Abdollah. Inhibition of phosalone-induced cellular senescence and apoptosis in rat embryonic fibroblasts by the Ellagic acid. (2016, Journal of Food and Chemical Toxicology).
13) Maryam Baeeri, Mona Navaei-Nigjeh, Kamal Niaz, Saeideh Momtaz, Mahban Rahimifard, Jaffari Abbas, Mohmmad Amin Rezvanfar, Mahdi Gholami, Seyed Alireza Salami, Mohammad Abdollahi. Cellular and Molecular Mechanisms of Aging and Stress-induced Senescence in Rat Embryonic Fibroblast Cells by Phosalone and Hydrogen Peroxide. (2016, Life Science, under publication).
حضور در کنفرانسهای علمی و پژوهشی
A. Momtaz, S & Lall, N. (13-14 September 2006). Anti-tyrosinase activity of South African plants. International Society of Cosmetic Chemists; Coschem, Johannesburg, South Africa (Oral presentation).
B. Momtaz, S & Lall, N. (November 2006). Anti-tyrosinase activity of eleven South African plants. Post-graduate students Symposium in the University of Pretoria (South Africa) (Oral presentation).
C. Momtaz, S & R.K. Chikwamba. (September 2005). The Importance of Plant Biotechnology in the Development of Biopharmaceuticals. Honours student Symposium in the University of Pretoria (South Africa) (Oral presentation).
D. Momtaz, S & Lall, N. (June 2006). HAIR GROWTH AND NATURAL PRODUCTS. Honours student Symposium in the University of Pretoria (South Africa) (Oral presentation).
E. Momtaz, S, Abdollahi, M & Ostad, SN., (May 2009). CYTOTOXICITY EFFECTS OF HYAENANCHE GLOBOSA AND MAYTENUS PROCUMBENS. 10 th Iranian Toxicology Congress, Tehran (Poster presentation).
F. Saeideh Momtaz, Namrita Lall, Ahmed Hussein, Seyed Nasser Ostad, Mohammad Abdollahi. AN EVALUATION OF ANTI-PROLIFERATIVE
: (Patent)
SA patent: "Plant extracts having anti-tyrosinase activity" (Granted on 26 May 2010 claiming priority from 15 October 2008). South African Patent No: ZA2009/06638. Inventors: N Lall, S. Momtaz and A.A. Hussein.
این گیاه در حال حاضر بصورت محصول تجاری در آمده و به عنوان کرگ روشن کننده روست با ناگ تجاری
"کالاهاری “Kalahari در کشور دانمارک تولید شده و در برخی کشورهای ارورایی از نمله سوئد و آلمان به
فروش میرسد.
